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- Increasingly stringent VOC regulations driven by air quality concerns demand creative measures. That’s why Hexion scientists developed the NextGen Epoxy™ Waterborne System – capable of less than 100 g/L VOC content in concrete and metal applications.
- ABOUT HEXON Established in 1989 Hexon Technology Pte Ltd is a leading premier company in the manufacturing of superior quality memory products and a strategic distributor of reputable IT & CE related products. For the last 2 decades, Hexon Technology had been manufacturing NCP®, a leading global OEM brand name in the memory industry.
Active Substance: diphtheria toxoid / filamentous haemagglutinin / hepatitis b surface antigen / pertussis toxoid / tetanus toxoid / haemophilus influenzae type b polysaccharide / polyribosylribitol phosphate conjugated to tetanus protein / type 1 (mahoney) / type 2 (mef-1) / type 3 (saukett)
Common Name: diphtheria (D), tetanus (T), pertussis (acellular, component) (Pa), hepatitis B (rDNA) (HBV), poliomyelitis (inactivated) (IPV) and Haemophilus influenzae type b (Hib) conjugate vaccine (adsorbed)
ATC Code: J07CA09
Marketing Authorisation Holder: Sanofi Pasteur Europe
Active Substance: diphtheria toxoid / filamentous haemagglutinin / hepatitis b surface antigen / pertussis toxoid / tetanus toxoid / haemophilus influenzae type b polysaccharide / polyribosylribitol phosphate conjugated to tetanus protein / type 1 (mahoney) / type 2 (mef-1) / type 3 (saukett)
Status: Authorised
Authorisation Date: 2013-04-17
Therapeutic Area: Meningitis, HaemophilusHepatitis BDiphtheriaPoliomyelitisWhooping CoughImmunizationTetanus
Pharmacotherapeutic Group: Vaccines
Common Name: diphtheria (D), tetanus (T), pertussis (acellular, component) (Pa), hepatitis B (rDNA) (HBV), poliomyelitis (inactivated) (IPV) and Haemophilus influenzae type b (Hib) conjugate vaccine (adsorbed)
ATC Code: J07CA09
Marketing Authorisation Holder: Sanofi Pasteur Europe
Active Substance: diphtheria toxoid / filamentous haemagglutinin / hepatitis b surface antigen / pertussis toxoid / tetanus toxoid / haemophilus influenzae type b polysaccharide / polyribosylribitol phosphate conjugated to tetanus protein / type 1 (mahoney) / type 2 (mef-1) / type 3 (saukett)
Status: Authorised
Authorisation Date: 2013-04-17
Therapeutic Area: Meningitis, HaemophilusHepatitis BDiphtheriaPoliomyelitisWhooping CoughImmunizationTetanus
Pharmacotherapeutic Group: Vaccines
Therapeutic Indication
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Hexyon (DTaP-IPV-HB-Hib) is indicated for primary and booster vaccination of infants and toddlers from six weeks of age against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and invasive diseases caused by Haemophilus influenzae type b (Hib).
The use of this vaccine should be in accordance with official recommendations.
The use of this vaccine should be in accordance with official recommendations.
What is Hexyon and what is it used for?
Hexyon is a vaccine containing active substances derived from diphtheria, tetanus, pertussis and Haemophilus influenzae type-b bacteria, the hepatitis-B virus, and inactivated polioviruses. It is used in babies and toddlers aged from six weeks to protect against the following infectious diseases:
- diphtheria (a highly contagious disease that affects the throat and skin, and can cause damage to the heart and other organs);
- tetanus (lockjaw, usually caused by infection of a wound);
- pertussis (whooping cough);
- hepatitis B (a viral liver infection);
- poliomyelitis (polio, a disease that affects the nerves and can lead to muscle weakness or paralysis);
- invasive diseases (such as meningitis) caused by H. influenzae type-b bacteria.
How is Hexyon used?
Hexyon is available as a suspension for injection in vials and prefilled syringes. It can only be obtained with a prescription. Vaccination with Hexyon should be carried out according to official recommendations. The recommended initial vaccination schedule is either two doses, given two months apart or three doses, given at least one month apart. A booster dose should be given at least six months after the last of these initial doses. Hexyon or an appropriate combination of other vaccines can be used for the booster dose. Hexyon is given by deep injection into a muscle, normally in the upper thigh or the shoulder.
For further information, see the package leaflet.
How does Hexyon work?
Hexyon is a vaccine. Vaccines work by ‘teaching’ the immune system (the body’s natural defences) how to defend itself against diseases. Hexyon contains small amounts of materials derived from the bacteria and viruses it protects against. These materials have been inactivated where necessary so that they do not cause any disease.
When a child is given the vaccine, the immune system recognises the parts of the bacteria and viruses as ‘foreign’ and makes antibodies against them. The immune system will then be able to produce antibodies quickly when the person is naturally exposed to the bacteria or viruses. This helps to protect against the diseases that these bacteria and viruses cause.
The vaccine is ‘adsorbed’. This means that some of the active substances are fixed onto aluminium compounds, to stimulate a better response.
What benefits of Hexyon have been shown in studies?
Hexyon has been studied in several countries worldwide in 12 main studies involving over 3,400 children between six weeks and two years of age who were given three doses of the vaccine during their first six months of life according to different local vaccination schedules. The effects were compared with a combination of separate vaccines designed to protect against the diseases included in Hexyon. The main measure of effectiveness was the production of antibody levels known to be protective against those diseases.
Five of these studies examined the effect of giving a booster dose at least 6 months after the initial vaccination schedule in 1,511 children. The studies showed that protective antibody levels against the various diseases developed in between 90 and 100% of children after the first three doses of Hexyon; protection was maintained or improved when a booster dose was given.
A subsequent study involving 455 children looked at the longer-term persistence of protective antibodies up to 3 years after a booster dose with Hexyon, and another study in 1336 children evaluated the response to different lots of the vaccine and what happened when it was given with vaccines for infections caused by the bacterium Streptococcus pneumoniae (Prevenar) and rotavirus (Rotarix). These studies showed that Hexyon produces similar antibody profiles over time to comparable vaccines, and that the vaccine can be given at the same time as Prevenar and Rotarix.
The two-dose vaccination schedule was investigated in an additional main study involving 554 children. In the study, children who either received Hexyon produced a similar antibody response to those who received a comparator vaccine (Infanrix hexa), when given as a two-dose schedule followed by a booster 6 months later.
What are the risks associated with Hexyon?
The most common side effects with Hexyon include pain and redness at the site of injection, irritability and crying. Reactions may be more likely after the first dose than later doses. For the full list of all side effects reported with Hexyon, see the package leaflet.
Hexyon must not be used in children who have ever had an allergic reaction to Hexyon or a vaccine containing the same components, including substances used during the manufacture of the vaccine and which may be found at extremely low levels (such as the antibiotics neomycin or streptomycin). It must not be used in children who have ever had encephalopathy (a brain disease) of unknown cause within seven days of receiving a vaccine containing pertussis components in the past. It must not be used in children who have an uncontrolled or severe illness affecting the brain or nervous system, such as uncontrolled epilepsy, unless the condition has stabilised with treatment and the benefit clearly outweighs the risk. Vaccination with Hexyon should be postponed if a child has a moderate to severe fever. For the full list of restrictions, see the package leaflet.
Why is Hexyon approved?
The Agency’s Committee for Medicinal Products for Human Use (CHMP) decided that Hexyon’s benefits are greater than its risks and recommended that it be approved for use in the EU.
Finale notepad mac download free. The CHMP noted that Hexyon has been shown to produce protective antibody levels against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and H. influenzae type b infections in children between six weeks and two years of age regardless of ethnicity. Although no data are available in children older than 2 years, there is no indication that older children would respond differently.
Regarding safety, the CHMP considered that Hexyon’s overall safety profile is similar to other vaccines, although vaccination with Hexyon is more likely than similar vaccines to cause reactions (mainly at the injection site).
Wireless communication by rappaport problem solution manual EEAD2674E7A46DE3A3A3284CAE19388E Wireless Communication By Rappaport. 1. Introduction to Wireless Communication Systems 1.2 Mobile Radiotelephone in the U.S. In 1946, the first public mobile telephone service was introduced in twenty- five major American cities. Each system used a single, high-powered transmitter and large tower in order to cover distances of over 50 km in a particular market.
What measures are being taken to ensure the safe and effective use of Hexyon?
Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Hexyon have been included in the summary of product characteristics and the package leaflet.
Other information about Hexyon
The European Commission granted a marketing authorisation valid throughout the European Union for Hexyon on 17 April 2013. Free download full games for mac.
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